Assessing patterns of dissolved methane in shallow aquifers related to Carboniferous and Triassic sedimentary basins, Nova Scotia, Canada

The study examines patterns of groundwater methane in shallow aquifers located in Carboniferous and Triassic sedimentary basins in Nova Scotia to improve our understanding of the factors influencing the observed distribution. A combined total of over 800 dissolved methane samples were collected from water wells during surveys conducted in 1975 and 2013. Statistical analyses of the methane data did not detect a significant difference between groupings of methane concentrations for aquifer type, bedrock group, and distance to wetlands. A significant difference, however, was observed between sedimentary basins and bedrock formations, which was largely attributed to localized higher methane concentrations found in the Stellarton Formation/basin compared to other on-shore sedimentary basins of the province. A significant difference was also found between groupings of methane data based on the distance to major stream systems, which was used to indicate topographic position (i.e., valley vs. upslope). The low sample density and percentage of detectable methane concentrations, and the multiple sources of dissolved methane in shallow groundwater in sedimentary basins made it difficult to detect and interpret statistical and spatial trends. Geochemical classification indicates that elevated dissolved methane in well water is associated with sodium dominated groundwater

Perspectives on local government’s place in federal systems and central–local relations

To expand on the themes identified by Tomas Hachard’s paper 'Capacity, voice and opportunity: advancing municipal engagement in Canadian federal relations', the Journal commissioned six personal ‘perspectives’ from a diverse group of other Commonwealth countries – Australia, India, New Zealand, Nigeria, South Africa and the United Kingdom. This replicated the model adopted in Issue 26 for Zack Taylor’s paper on 'Regionalism from above: intergovernmental relations in Canadian metropolitan governance'. Similarly, the purpose was to establish a broader picture of issues and trends across the Commonwealth, rather than ‘review’ Hachard’s work

Managing financial crises in emerging market economies - experience with the involvement of private sector creditors

Ensuring the involvement of private sector creditors in the resolution of sovereign debt crises is crucial to ensure an effective management and orderly resolution of those crises. A review of experience gained in past financial crises suggests that crisis management practices have been largely following a case-by-case approach. This has led to some uncertainty about how the official sector addresses different types of crises, which in turn might partially account for the very mixed results achieved so far. From a global welfare perspective, the resolution of international financial crises is too costly and takes too long. Efforts to improve predictability of crisis resolution processes – through guiding debtor, creditor and official sector behaviour – could lower overall costs of such crises and bring about a better distribution of these costs. Past experience with such private sector involvement shows that, in certain cases, existing instruments have successfully contributed to minimising the economic disruptions caused by crises. However, the effective use of these instruments requires predictable and strong commitment of all parties involved. Key variables in that regard are the country’s economic fundamentals and its track record prior to the crisis, underscoring the importance of effective surveillance and crisis prevention. Success also hinges on the country’s resolve to implement necessary domestic adjustment measures. A transparent process providing for early dialogue between a debtor and its creditors also facilitates private sector involvement. Finally, the IMF plays a key role in crisis situations, as accurate and timely diagnosis by the IMF helps identify at an early stage the need for private sector involvement.Sovereign default, bond restructuring, emerging markets, financial crises, moral hazard, international financial architecture.

Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study

BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe

Habitat connectivity and island biogeography: A call for community-engaged scholarship to address isolated parks and protected areas

Using the theory of island biogeography as a framework, we seek to determine the potential impact of the lack of connectivity between parks and protected areas on large-scale conservation efforts. We analyze lessons learned from the current Yellowstone to Yukon (Y2Y) initiative and develop recommendations to improve connectivity while incorporating the motivations, needs, and emotions of stakeholder groups. We strongly encourage ecologists, geographers, biologists, and other academics and activists to partake wholly and enthusiastically in community-engaged scholarship through outreach, capacity building, and social capital building through the proven frameworks of consensus-based and structured decisionmaking. Further, we argue that large-scale conservation initiatives may greatly benefit from an approach focused on small, more tangible actions when working toward a larger goal. As human populations and urban–wildland interfaces continue to grow rapidly, former models of park and protected area development become increasingly ineffective. We must adopt new strategies, such as those listed here, in order to increase landscape connectivity and provide effective conservation for all species. [This is a paper from “Systemic Threats to Parks & Protected Areas,” the 2020 George Wright Society Student Summit.